Intracellular calcium and neurotoxic events
نویسندگان
چکیده
منابع مشابه
Intracellular calcium events activated by ATP in murine colonic myocytes.
ATP is a candidate enteric inhibitory neurotransmitter in visceral smooth muscles. ATP hyperpolarizes visceral muscles via activation of small-conductance, Ca(2+)-activated K(+) (SK) channels. Coupling between ATP stimulation and SK channels may be mediated by localized Ca(2+) release. Isolated myocytes of the murine colon produced spontaneous, localized Ca(2+) release events. These events corr...
متن کاملNeuronal calcium sparks and intracellular calcium "noise".
Intracellular calcium ions are involved in many forms of cellular function. To accommodate so many control functions, a complex spatiotemporal organization of calcium signaling has developed. In both excitable and nonexcitable cells, calcium signaling was found to fluctuate. Sudden localized increases in the intracellular calcium concentration-or calcium sparks-were found in heart, striated and...
متن کاملIntracellular Calcium and Ventricular Fibrillation
To elucidate the role of changes in [Ca2+]l in the induction of ventricular fibrillation (VF), Ca'i signals, epicardial electrical potentials, and isovolumic left ventricular pressure were simultaneously recorded in isolated intact ferret hearts loaded with aequorin, a bioluminescent protein. When the preparations were perfused with 3 ,uM acetylstrophanthidin and 8 mM Ca', or with a low Na+ sol...
متن کاملOptimal intracellular calcium signaling.
In many cell types, calcium is released from internal stores through calcium release channels upon external stimulation (e.g., pressure or receptor binding). These channels are clustered with a typical cluster size of about 20 channels, generating stochastic calcium puffs. We find that the clustering of the release channels in small clusters increases the sensitivity of the calcium response, al...
متن کاملIntracellular calcium signaling.
In excitable cells, the major pathway for Ca2+ influx is via highly Ca2+-selective voltage-gated Ca2+ channels (VGCC). The original alphabetical nomenclature was replaced recently with standard numerical nomenclature: Cav1.1-1.4, Cav2.1-2.3, Cav3.1-3.3. In skeletal muscle cells, an additional voltagesensitive pathway is provided by dihydropyridine receptors (DHPR, Cav1.1) that do not pass signi...
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ژورنال
عنوان ژورنال: Neurotoxicology and Teratology
سال: 1989
ISSN: 0892-0362
DOI: 10.1016/0892-0362(89)90032-9